Keyword Suggestions

L4.06 - Which Tool in the Toolbox? Functional Diversity across the Kinesin Superfamily 
April 8, 2015   3:30pm - 4:00pm

Different nanoscale transport and actuation applications require different motor properties, and insights into fundamental molecular mechanisms can be gained by studying the natural diversity found in nature. Kinesin motors have evolved to carry out diverse transport processes in cells, and thus they provide a valuable toolbox of motors that move at different speeds, have different abilities to generate sustained forces, and possess different affinities for their microtubule tracks. I will discuss work in my lab to understand the specific adaptations of transport (kinesin-1,2 and 3 family) and mitotic (kinesin-5 and 7 family) kinesins, and will describe nanoscale tracking experiments we are carrying out to understand the nanoscale dynamics of each motor domain as it walks along the microtubule. Understanding this diversity across the kinesin superfamily both aids in choosing optimal motors for optimal applications, as well as helping to understand how the activities of many motors can (or can�t) sum to achieve maximal performance.

Average Rating: (No Ratings)
  Was great, surpassed expectations, and I would recommend this
  Was good, met expectations, and I would recommend this
  Was okay, met most expectations
  Was okay but did not meet expectations
  Was bad and I would not recommend this

Group III-Sb Metamorphic Buffer on Si for p-Channel all-III-V CMOS: Electrical Properties, Growth and Surface Defects
Kinetics and Structure of Nickelide Contact Formation to InGaAs Fin Channels
Recent Progress in Understanding the Electrical Reliability of GaN High-Electron Mobility Transistors
The Effect of ALD Temperature on Border Traps in Al2O3 InGaAs Gate Stacks
Atomic Layer Deposition of Crystalline SrHfxTi1-xO3 Directly on Ge (001) for High-K Dielectric Applications