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A8.03 - Conducting Polymer Based Devices for Neural Recordings 
Date/Time:
December 3, 2014   2:15pm - 2:30pm
 
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Neural signals play an important part in central nervous system physiology while their role is also essential in the understanding of neurological disorders. However, the recording of these signals can be a challenging task mostly due to the difficulties in the coupling between conventional electronics and biological systems. Lately, conducting polymers have emerged as one of the most promising candidates for the next generation devices in neural activity recording both in vitro and in vivo. Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT: PSS) ,in particular, has the unique ability to conduct both electronic and ionic carriers, offering a high performing platform for communication between biological systems and electronics. Furthermore, it demonstrates ease of processability and property tunability in contrast with its inorganic counterparts. Here, we demonstrate the use of PEDOT:PSS devices for in vitro measurements. Using PEDOT:PSS coated electrodes we were able to record neural activity ,such as local field potentials (LFPs) and action potentials (APs), both from hippocampal brain slices and from primary hippocampal cells. We also investigated the possibility to achieve similar recordings with Organic Electrochemical Transistors (OECTs).These devices, due to local amplification compared with electrodes, promise superior signal to noise ratio during the measurements. Our results demonstrate that PEDOT: PSS dramatically improves the resolution of electrophysiology and pave the way for the use of active devices such as OECTs in neural recordings. Furthermore, the PEDOT:PSS devices presented here provide a vehicle for fundamental research in the life sciences, facilitates the study of neural activity and opens new horizons in the understanding of the physiology and the neuropathology of the central nervous system.
 


 
 
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