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A8.01 - Conjugated Polythiophene Copolymers for Interfacing Devices with Cells 
December 3, 2014   1:30pm - 2:00pm

We are investigating the design, synthesis, and characterization of conjugated polymers such as poly(ethylene dioxythiophene) (PEDOT) and poly(propylene dioxythiophene (PProDOT) for interfacing a variety of electronically-active biomedical devices with living tissue. We have developed a variety of novel EDOT and ProDOT monomers with carboxylic acid, amine, and alkene functional groups. These new materials make it possible for us to systematically tailor the surface chemistry and promote specific interactions with solid inorganic substrates as well as living cells both in vitro and in vivo. We are also examining the polymerization of PEDOT and PProDOT into a variety of media including cell-laden hydrogels, ordered non-ionic surfactants, and living tissue. In this talk we will discuss the most recent results from these ongoing efforts, including characterization results from optical and electron microscopy; UV, visible and infared spectroscopy, and biological assays. We will also examine the mechanical properties of the resulting films, including their adhesion on solid substrates.

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