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A1.06 - DNA as a Molecular Wire: Distance and Sequence Dependence 
December 1, 2014   10:30am - 10:45am

Charge transport (CT) through DNA has been extensively studied, and yet the mechanism of this process is still not yet fully understood. Besides the benefits of understanding charge transport through this fundamental molecule, further understanding of this process will elucidate the biological implications of DNA CT and advance sensing technology. Therefore, we have investigated the temperature and length dependence of DNA CT by measuring the electrochemical response of DNA monolayers modified with a redox-active probe. By using multiplexed electrodes, we are able to compare square wave voltammetry of distinct DNA sequences under identical experimental conditions. We vary the position of the probe, within a well matched DNA duplex, in order to investigate distance dependent kinetics. Through modeling analysis we are able to determine the charge transfer rates (k), transfer coefficients (α), and the redox active surface concentration (Γ*) of the DNA monolayer. The yield of transport is strongly connected to the stability of the duplex, linearly correlated to the melting temperature of the duplex. Additionally, the results show Arrhenius like behavior for multiple probe locations, with the transport rates following a 1/L length dependence, consistent with a hopping mechanism of transport. These results begin to clarify the significance of length and sequence on the stability of the duplex, which in turn, may be used to establish the guidelines for using DNA as a molecular wire in nanoscale electronics and sensing applications

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