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W1.07 - Graphene-Hydroxyapatite Biocompatible Nnanomateriales 
Date/Time:
April 22, 2014   11:00am - 11:15am
 
Taxonomy
C 
 
 
 
 
 
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Tissue engineering is a branch of science that deals with the design and synthesis of biomaterials with properties such that promote tissue regeneration by cell proliferation and differentiation. Biocompatible polymers have been widely investigated for the development of biomaterials due to their low cytotoxicity, together with its ability to form polymeric scaffolds with morphology suitable for mechanical support of the tissue. Also, various techniques have been developed which allow functionalization of polymeric scaffolds in order to improve such mechanical and biological properties, thus yielding, high quality hybrid materials with application in the area of tissue engineering. In this study, graphene oxide sheets (GrO) were functionalized with hydroxyapatite nanoparticles (nHAp) through a simple and effective hydrothermal treatment and a new physicochemical process. Microstructure and crystallinity of the new hybrid nanomaterial GrO/nHap were investigated by Fourier transform infrared spectroscopy (FT-IR), Raman spectroscopy, X-ray diffraction (XRD) and thermo-gravimetric analysis (TGA). Transmission electron microscopy (TEM) and scanning electron microscopy (SEM) were performed to characterize the morphology of the functionalized material. To analyze biological properties, the composite material was functionalized using three different GrO:nHap ratios. In order to evaluate the cytotoxicity and cell proliferation the obtained materials were subjected to a MTT assay using the NIH-3T3 cell line. Polymeric scaffolds based in chitosan-polyvinyl alcohol (PVA-Ch) co-polymer were fabricated, integrating the hybrid material GrO/nHap at different concentrations (1-5 wt %), using a physical technique. The morphological characteristics of the resulting biomaterials were observed by SEM. The technique parameters were modified to increase the surface area and pore size of the biopolymer scaffolds. Confocal electron microscopy and SEM were performed to observe cell adhesion on the composite. Cell viability of the polymeric scaffolds reinforced with the hybrid materials was measured by MTT assay, using the same cell line described before. The mechanical and physical properties will be characterized using thermal analysis (TGA and DSC) and mechanical tester. The resulting novel materials combine the biocompatibility of the nHap with the strength and physical properties of the graphene improving the properties of the polymer matrices, thereby obtaining a biomaterial with potential applications in tissue engineering.
 


 
 
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