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Z1.08/AA1.08 - In-Situ Polymerization of Conjugated Polymers in Rat Hippocampus: Histology of Local Tissue Response and Retention of Memory 
Date/Time:
April 22, 2014   11:30am - 12:00pm
 
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The long-term performance of introcortical neural probes is often complicated by a foreign body reaction that consists of accumulation of microglia, neuronal apoptosis and an insulating glial sheath around the implants. This extensive gliosis has been associated with the system impedance increase and signal deterioration and loss of the devices. Previously we have proposed that the in vivo polymerization of a conducting polymer, poly (3,4 ethylene dioxythiophene) (PEDOT), in living tissue may help to build a conducting pathway between the retreated neurons and the probe. The EDOT monomer can be infused into the tissue with a microcannula/electrode guide followed by electrochemical polymerization under the oxidative current through the electrodes. Here we examined the effects of this in vivo method by polymerizing PEDOT in living rat hippocampus at different time points post initial device implantation. We found that the system impedance was decreased for all the groups regardless of scarring stage. However, there seemed to be an optimal time window for sustained impedance improvement. The tissue responses to the polymer were examined with immunohistology. We also investigated the effects of polymerization on local neural function with a hippocampus-dependent behavior test, delayed alternation (DA). Compared to the control groups, in vivo polymerization did not cause significant deficit on the hippocampal function.
 


 
 
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