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Z1.07/AA1.07 - Recording Neural Activity with Organic Electrochemical Transistors 
April 22, 2014   11:15am - 11:30am

Organic electrochemical transistors (OECTs) have been targeted for a variety of and diagnostic applications owing largely to their efficient transduction of ionic to electronic signals. In these devices, the transistor drain current is modulated by de-doping of the PEDOT:PSS {poly(3,4-ethylenedioxythiophene) doped with poly(styrene sulfonate)} channel due to local variations of ion flux induced by, for example, neural activity. Owing to the efficient ion mobility and high capacitance in hydrated PEDOT:PSS, we are able to fabricate devices with high intrinsic amplification (transconductance), and when scaled to micron dimensions, broad-band response up to 10 kHz. Along with facile and robust/conformal fabrication schemes, these devices show great promise for a number of neuroscience applications. By studying film morphology and by systematically varying OECT device geometry, we develop a fundamental understanding of device operation and establish design rules for practical implementation of OECTs and , for both research and clinical applications. Considering the recording capabilities of common measurement techniques, and the nature (amplitude, frequency) of neural signals, we describe how a tradeoff between OECT device response time and transconductance can be navigated. With this scheme, we demonstrate the use of OECTs to record low amplitude, low frequency neural oscillations, high amplitude epileptiform activity, and show that measurements of individual action potentials are within reach. Thus, these devices can be tailored for various applications depending on the desired or required content of neural signals.

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Keynote Address
Panel Discussion - Different Approaches to Commercializing Materials Research
Business Challenges to Starting a Materials-Based Company
Fred Kavli Distinguished Lectureship in Nanoscience
Application of In-situ X-ray Absorption, Emission and Powder Diffraction Studies in Nanomaterials Research - From the Design of an In-situ Experiment to Data Analysis