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Biodegradable Polymersomes Engineered with Bcl-xL siRNA- and Doxorubicin-loaded Core-shell for Combined Cancer Therapy 
April 22, 2013   9:00am - 10:00am
  Video Only

Combined therapy via simultaneous administration of multiple medications is a universal and highly effective strategy to treat cancer due to the unique metabolic divergences of this disease. Generally, combined treatment with drug and genetic components exhibits superior therapeutic efficacy compared with administration of the individual treatments, respectively. This is mainly because i) cytotoxic chemotherapeutic agents primarily affect the dividing cells and cause cell death through apoptosis, and ii) genes further induce additive cell killing effect and/or increase the sensitivity of cancer cells to chemotherapeutic agents, thus synergistically increasing therapeutic efficacy. For the simultaneous delivery of drug and gene while maintaining their chemophysical properties and biological functions, sophisticated nanocarriers have been designed.

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